MBBS · Biochemistry · TOPIC 01 Glycolysis Embden–Meyerhof pathway · 10 cytosolic steps · Net +2 ATP, +2 NADH Glycolysis is the central glucose-using pathway in human biochemistry. Every cell can do it. Some cells — most importantly, mature red blood cells — depend on it entirely, because they have no mitochondria. The brain runs heavily on it. The renal medulla too. Even tumours rely on it preferentially, even in the presence of oxygen, for reasons we’ll come to (the Warburg effect ). Three things make the pathway worth understanding deeply: ▸ It runs with or without oxygen — t…
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